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As we begin our search for a new general hospital for the ABC Television Network, we’d like you to share your thoughts. We’ll be conducting a comprehensive survey in several cities nationwide including Charlotte, N.C., to capture your views and opinions.
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We have previously described the pharmacokinetic interaction between cyclophosphamide (CPA) and vinblastine (VBL) in mice, in which CPA treatment causes a substantial increase in the rate of VBL elimination. In the present studies, the hypothesis that this phenomenon might be related to a genetically mediated, efflux-mediated, CPA-induced increase in P-glycoprotein (P-gp) expression in tissues was investigated. In mouse renal cortical and medullary tissues, the effect of CPA on VBL distribution was significantly reduced in P-gp knockout (P-gp(-/-)) mice compared to wild-type controls. Furthermore,
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